Effects of N-n-butyl haloperidol iodide on ischemia and reperfusion-induced ventricular arrhythmias in rat heart

Abstract

Abstract: AIM: To study the antiarrhythmic effects of N-n-butyl haloperidol iodide (F₂) on ischemia- and reperfusion-induced ventricular arrhythmias.METHODS: Using the Langendorff-perfused rat heart model, the ventricular arrhythmias were induced by ligating the left anterior descending coronary artery for 20 minutes before the release of the ligature.Each concentration of F₂ was administered 5 min prior to the induction of regional ischemia.The effects of F₂ on arrhythmias during periods of ischemia and reperfusion and the effects on PR, QT, RR intervals were investigated.When rat hearts were paced (5 Hz) via the right atrium to prevent bradycardia, the antiarrhythmic effects and the effect on PR interval of 1 μmol/L F₂ were observed.RESULTS: F₂ reduced ischemia- and reperfusion-induced ventricular arrhythmias in concentration-dependent manner, and widened PR, RR intervals.The same effects were observed even in paced rat hearts.CONCLUSION: F₂ could reduce ischemia- and reperfusion-induced ventricular arrhythmias directly in the isolated rat hearts.

Key words: N-n-butyl haloperidol iodide, arrhythmia, ischemia-reperfusion

CLC Number:

R971.4

GAO Fen-fei, SHI Gang-gang, LI Hai-qing, HUANG Zhan-qin, ZHANG Yan-mei, ZHOU Yan-qiong. Effects of N-n-butyl haloperidol iodide on ischemia and reperfusion-induced ventricular arrhythmias in rat heart[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(9): 1004-1008.

References

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