Experimental study on the protective effect of total glycosides of Zhizi for ulceration in pylorus ligature rats

Abstract

Abstract: AIM: To investigate the antiulcer effect and concerned mechanism of total glycosides of Zhizi (TGZ) in pylorus ligature rats (Shay-rats). METHODS: Pylorus-ligation induced gastric ulceration in rats(Shay-rats model).Quantity determined the free acid, total acid contents and pepsase activity in gastric juice.The effect of TGZ on gastric mucosal lesion index in rats was also determined. RESULTS: TGZ 70 or 140 mg/kg injection gavage for five days versus shay model rats could significantly prevent gastric ulceration decreased free acid, total acid contents and pepsase activity of gastric juice. CONCLUSION: TGZ, through inhibiting gastric acid and pepsase activity evokes its anti-ulceration.

Key words: total glycosides of Zhizi, peptic ulcer, rat

CLC Number:

R965.2

JU Jing. Experimental study on the protective effect of total glycosides of Zhizi for ulceration in pylorus ligature rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(10): 1106-1109.

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Experimental study on the protective effect of total glycosides of Zhizi for ulceration in pylorus ligature rats

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