Research progress of thalidomide in combination therapy for the treatment of tumor

Abstract

Abstract: Following the reports of its teratogenicity, thalidomide was banned from the market in the 1960s.Later, researches discovered the teratogenicity was caused by inhibiting angiogenesis, and at that time the antiangiogenesis effect was considered an important factor in anti-tumour.Since then, many other anti-tumour mechanisms of thalidomide had been revealed and thalidomide was considered a kind of potential antitumor drug and was researched widely.This article focuses on the anti-tumour mechanisms of thalidomide and its use in combination therapy for the treatment of solid tumor.

Key words: thalidomide, anti-tumour, combination therapy

CLC Number:

R730

YU Shan, JI Hui. Research progress of thalidomide in combination therapy for the treatment of tumor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(2): 230-236.

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