Effects of sodium-calcium exchanger and its inhibitors on cerebral ischemia

Abstract

Abstract: In neural cell, Na⁺/Ca²⁺ exchanger (NCX)is thought to play an important role in the regulation of intracellular Ca²⁺ concentration.During the cerebral ischemia/reperfusion, the influxion of Ca²⁺ though NCX reverse mode induce calcium overload, which make neural cell damage.Recently, the benzyloxyphenyl derivatives have been developed as selective NCX inhibitors, which may have therapeutic potential as a new remedy for cerebral ischemia.

Key words: Na⁺/Ca²⁺ exchanger, reverse mode, calcium overload, Na⁺/Ca²⁺ exchanger inhibitor, ischemia/reperfusion

CLC Number:

R743

ZENG Wen-jun, SHEN Lei, WU Yu-lin. Effects of sodium-calcium exchanger and its inhibitors on cerebral ischemia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(2): 237-240.

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