Effects of tea polyphenols on the serum lipid and inflammation factor in experimental atherosclerosis rabbits

Abstract

Abstract: AIM: To investigate the effects of tea polyphenols (TP) on the serum lipid, the anti-oxidant system and inflammaory factor in experimental atherosclerosis (AS) rabbits. METHODS: Experimental AS model of rabbits was made by feeding high fat diet (HFD).All rabbits were treated with TP (i.g., 100 mg·kg ^-1 ·d^-1) or vehicle for 12 weeks.The contents of TC, TG, HDL-C, LDL-C, NO, CRP, IL-6, TNF-α, SOD and GSH-Px in serum were measured.And the pathomorphological changes of aorta were observed. RESULTS: TP could effectively reduce the area of atherosclerotic plaques in HFD treated rabbits.It also decreased the plasma levels of TC, TG and LDL-C in hyperlipemia rabbits(P<0.01).At the same time, TP treatment lead to the up-regulation of plasma HDL-C levels(P<0.01) and SOD, GSH-Px activity.Moreover, it could decrease the plasma levels of NO, CRP, IL-6 and TNF-αin HFD treated rabbits(P<0.01). CONCLUSION: The anti-atherogenic effect of TP seems to be related to reducing serum lipids, preventing lipid hyperoxidation and inhibiting the production of inflammatory factor.

Key words: tea polyphenol, rabbit, atherosclerosis, inflammatory factor

CLC Number:

R589.205

DENG Zu-yue, KANG Hua, XIN Yan-fei, KUANG Rong. Effects of tea polyphenols on the serum lipid and inflammation factor in experimental atherosclerosis rabbits[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(3): 279-282.

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