Simvastatin inhibits migration of nasopharyngeal carcinoma -2( CNE2)cells

Abstract

Abstract: AIM: To study the effect of simvastatin on cells migration of nasopharyngeal carcinoma cell line CNE2 in vitro.METHODS: The depressive effects of simvastatin on CNE2 cells migration were observed by scratch wound healing assay and transwell migration assay.RESULTS: The experimental result of scratch wound healing assay showed that simvastatin inhibited migration of nasopharyngeal carcinoma CNE2 cells in a time-and dose-dependent manner.With 2.5 μmol/L simvastatin treatment for 24 hs, the migration lenth was 50.1 % of that in control group.Transwell experimental result indicated that with 2.5 μmol/L simvastatin treatment for 24 hs, the migrating cell population was 69.2 % of that in control group.CONCLUSION: Simvastatin can inhibits CNE2 cells migration in a time-and dose-dependent manner, which can provide rational clues for clinical research of simvastatin.

Key words: simvastatin, nasopharyngeal carcinoma, migration

CLC Number:

R965.2

TU Yong-sheng, WANG Hong-yan, XU Ji-de, LI Jian-hua, PENG Miao-ru, LIU Xiao-ai. Simvastatin inhibits migration of nasopharyngeal carcinoma -2( CNE2)cells[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(4): 401-404.

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Simvastatin inhibits migration of nasopharyngeal carcinoma -2( CNE2)cells

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