Effects of leonurine on uterus induced by drug-abortion in rats

Abstract

Abstract: AIM:To study the effects of leonurine on uterus induced by drug abortion in rats. METHODS: Early pregnancy rats were intragastrically (i. g.) administrated with mifepristone(8. 3 mg/kg) and misoprostol(100 μg/kg) to induce incomplete abortion model. The changes of uterine bleeding amount and time, its morphous were observed in incomplete abortion model rats. The residues of decidual membranes and chorionic villus were observed with light microscope. The levels of estradiol(E₂) and progesterone in blood serum were detected by radioimmunoassay (RIA), the contraction activity of rat uterine smooth muscle by BL- 420E biological function of the experimental system and JH-2 muscular tension sensor. RESULTS:Compared with model group, leonurine markedly reduced the uterine bleeding amount and time, the intrauterine residues were reduced significantly and the contraction activity of rat uterine smooth muscles was strengthened obviously, the level of E₂ in serum was higher (P <0. 01). CONCLUSION:Leonurine has an obvious depressant effect on uterus haemorrhage induced by drug-abortion, which could result from the enhancement of the level of E₂ and the contraction activity of rat uterus.

Key words: leonurine, drug abortion, uterus, rat

CLC Number:

R711

LI Xia, CHEN Fei-hu, YUAN Feng-lai, LU Wei-guo, WU Fan-rong, ZHANG Yan-na, LI Xiao-xiang. Effects of leonurine on uterus induced by drug-abortion in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(5): 481-486.

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