Research advances of the effects of hydrogen sulfide on central nervous system

Abstract

Abstract: In mammalian central nervous system (CNS), hydrogen sulfide (H₂S) is predominately formed from the amino acid cysteine by the action of cystathionine β-synthase (CBS) and the biosynthesis of H₂S is regulated by the intracellular concentration of calcium and S-adenosylmethionine which acts as an allosteric activator of CBS.A rapidly accumulating body of evidence is now available suggesting that H₂S acts as a gaseous mediator or gasotransmitter in mammalian CNS.Reported physiological functions of H₂S include maintenance of calcium homeostasis, potentiation of long-term potentiation (LTP), suppression of oxidative stress, and modulation of neurotransmission.H₂S, functions as a neuromodulator, exerts both potentiates or inhibits biological effects through a variety of mechanisms.Besides its pro-reducing properties, H₂S is able to stimulate the production of cAMP, active ATP-activated potassium channels,and increase intracellular calcium.H₂S is also involved in the pathology of central nervous system (CNS) such as stroke and Alzheimer's disease.Latest studies suggest controlling the content of H₂S can play a protective role in the treatment in some disease models. H₂S holds the potential of therapeutic value for CNS diseases.

Key words: Hydrogen sulfide, Gaseous moderator, Central nervous system diseases

CLC Number:

R965.2

LI Kang-qi, ZHANG Guang-qin. Research advances of the effects of hydrogen sulfide on central nervous system[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(10): 1183-1188.

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