Study progress of type I anaphylaxis reaction and anaphylactoid reaction on the basis of RBL-2H3 cell models

Abstract

Abstract: It have been apparently considerable research work on type I anaphylaxis reaction since it was discovered in early 20th.Anaphylactoid reaction was first described in application of anaesthetic and contrast medium in 1980s.With the ascending rate of anaphylactoid responses accompanied the increasing use of traditional Chinese medicine injections, much attention has been paid to this field in order to clarify the mechanism.This article focuses on the cell model of type I and pseudoallergic reaction based on RBL-2H3 cell with the latest detection methods and molecular mechanism in vitro.

Key words: RBL-2H3 cell model, Anaphylaxis reaction, Anaphylactoid reaction, Drug screening, Molecular mechanism

CLC Number:

R392.8

ZHAO Yin, LI Qin, ZHANG Xin-yue. Study progress of type I anaphylaxis reaction and anaphylactoid reaction on the basis of RBL-2H3 cell models[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(11): 1310-1314.

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