Protective effect of glycosides of Cistanches on CCl4 damaged mice

Abstract

Abstract: AIM: To investigate the protective effect of glycosides of Cistanches (GCs) on CCl₄ damaged mice.METHODS: 40 mice were randomly divided into 4 groups, control group,CCl₄ model group,Cistanches groups (62.5,125 mg·kg^-1·d^-1). The acute liver damage mode was established by CCl₄ peanut oil in mice. The mice were received intragastric administration twice a day. After 14 d,the effect of GCs on ALT, AST, ALP and pathological changes were detected.RESULTS: GCs could obviously reduce the levels of ALT, AST and ALP in CCl₄ damaged mice, as well as moderating hepatocyte cytoclasis.CONCLUSION: GCs has protective effect on CCl₄ damaged mice.

Key words: Glycosides of Cistanches, CCl₄, ALT, AST, ALP

CLC Number:

R965.2

LUO Hui-ying, YANG Huan, ZHU Li-juan, GAO Zhong-qing, YANG Hai-lin. Protective effect of glycosides of Cistanches on CCl₄ damaged mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(12): 1358-1361.

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Protective effect of glycosides of Cistanches on CCl₄ damaged mice

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