Effect of mild hypothermia therapy on the concentration of plasma C-Reactive protein following acute severe brain injuries

Abstract

Abstract: AIM: To observe the effect of mild hypothermia therapy on concentration of plasma C-reactive protein following acute severe brain injuries and to explore the treatment effect of mild hypothermia on acute severe brain injury patients. METHODS: A total of 120 patients with acute severe brain injuries were divided into mild hypothermia therapy group and general group randomly. The patients of mild hypothermia therapy group were treated with mild hypothermia therapy besides general treatment. Serial concentrations of C-reactive protein in serum were measured in all patients from 6 h to 6 d after hospitalization. RESULTS: The concentration of C-reactive protein in serum of both groups were significantly higher than those of normal group(P<0.05); The concentration of C-reactive protein in serum of mild hypothermia therapy group were significantly lower than those of general group(P<0.05); The concentrations of C-reactive protein in serum in the group with poor prognosis were higher than those in the group with sound prognosis. CONCLUSION: The concentration of C-reactive protein in serum was elevated significantly after acute severe brain injuries, mildhypothermia could decrease the concentration of C-reactive protein in serum, protect the neurofunction and improve the prognosis.

Key words: Mild hypothermia, Acute severe brain injury, C-reactive protein

CLC Number:

R651

CHEN Zai-feng , XU Xin-long, FU Xiao-jun, WEI Xiao-jie, PAN Hong-song, XIE Qin-song, SHI Bin-qun. Effect of mild hypothermia therapy on the concentration of plasma C-Reactive protein following acute severe brain injuries[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(2): 210-213.

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