Effect of Helicid on the behavior in chronically stressed mice

Abstract

Abstract: AIM: To study the effect of Helicid on the behavior in chronically stressed mice. METHODS: Mice were exposed to chronic mild stress(CMS) and isolated breed for 28 consecutive days with coadministration of Helicid (40,20,10 mg/kg, i.g. ) or Fluoxetine (2.6 mg/kg, i.g.).The open field test, sucrose preference test and emotional behavior score were applied to assess the behavior efficacy. RESULTS: Helicid or Fluoxetine treatment reversed depression-like behaviors such as deficient locomotory, reduced sucrose preference, emotional behavior score and weight. CONCLUSION: Helicid has an obviously antidepressant effect in chronically stressed mice.

Key words: Helicid, Antidepressant, Chronic stress, Behavior, Animal

CLC Number:

R965

TONG Jiu-cui, XIE Hai-tang, YANG Bin, CHEN Ai-dong, LI Hai-gang, PAN Hang-shan, JIA Yuan-wei, ZHONG Min, JIANG Si-yan. Effect of Helicid on the behavior in chronically stressed mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(6): 641-645.

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