Animal models for brain ischemia and its application in experimental therapeutics

Abstract

Abstract: Brain ischemia, also known as cerebral ischemia, is due to insufficient blood flow to specific parts of the brain to meet metabolic demand, resulting poor oxygen supply or cerebral hypoxia and thus to the death of brain tissue or cerebral infarction/ischemic stroke.Currently pathophysiological mechanism of brain ischemia and nerve repair therapy following ischemia brain injury is one of the hottest issues in neuroscience research.Duplicating animal models for brain ischemia plays a vital role in promoting the investigation of experimental therapeutics.This article systemically reviews the methodological literature of animal models for global brain ischemia and focal cerebral ischemia, which has been established at home and abroad. Based upon the aforementioned models, their strengths and weaknesses and some typical applications in experimental therapeutics are simultaneously enumerated. All these information provides scientific guidance for the experimental neuroprotectant drug's pharmacodynamics screening.

Key words: Brain ischemia, Animal model, Global brain ischemia, Focal brain ischemia, Experimental therapeutics

CLC Number:

GU Bing, CHENG Xiang, JIN Jian-bo, YU Ri-yue. Animal models for brain ischemia and its application in experimental therapeutics[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(9): 1074-1080.

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