Study of Prostat on SD rat with nonbacterial chronic prostatitis

Abstract

Abstract: AIM: To investigate the therapeutic effect and mechanism of Prostat on two kinds of nonbacterial chronic prostatitis.METHODS: Two kinds of non-bacterial chronic prostatitis models, including chemical and autoimmunity, were established by injecting carrageenan into the rat's prostate and intracutaneous injection protein respectively. The two models were respectively treated with Prostat consistent with clinical way, observed histopathology changes of prostate gland, testicle and epididymis, and sperm activity, hematology, blood serum biochemistry, hormone and prostate gland special antigen were detected.RESULTS: Compared with control group, the levels of serum Ca²⁺ and testosterone (T) in autoimmunity model after treated with Prostat were significant increased (P<0.05), and there were significant decreased (P<0.05) in white blood-cell count in the chemical model group after treated with Prostat. The histopathology changes of prostate in two models showed that congestion and edema reduced obviously.CONCLUSION: Prostat has an effect on the two models of nonbacterial chronic prostatitis, and the mechanism is different.

Key words: Autoimmunity prostatitis, Chemical prostatitis, SD rat, Prostat

CLC Number:

R965.1

YAN Han, ZHOU Li, LI Dong-mei, LIU Xiang-yun, SUN Zu-yue. Study of Prostat on SD rat with nonbacterial chronic prostatitis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(11): 1234-1238.

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