Development of microRNA-dependent control of cytochrome P450

Abstract

Abstract: MicroRNAs (miRNAs) are a class of short, non-coding RNAs of 19-25 nucleotides that negatively regulate gene expression by inducing translational inhibition or cleavage of their target mRNAs through binding to the 3′-untranslated regions of target messenger RNAs (mRNAs). Since miRNAs regulate every aspect of cellular function, their dysregulation is associated with a variety of diseases.Therefore, miRNAs are now considered new therapeutic targets.However, the roles of miRNAs in pharmacogenetics have only recently been revealed. The miRNA expression is readily altered by chemicals, drugs, hormones or diseases, and the dysregulation of specifc miRNAs might lead to changes in the drug pharmacokinetics or pharmacodynamics changes. This review describes the current knowledge on the post-transcriptional regulation of cytochrome P450s and nuclear receptors by miRNAs.

Key words: MicroRNA, Cytochrome P450, Pharmacogenetics, Post-transcriptional regulation

CLC Number:

R968

WEN Chun-jie, FU Li-juan, WU Lan-xiang, CHEN Wang, ZHANG Tao, ZHOU Hong-hao. Development of microRNA-dependent control of cytochrome P450[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(11): 1304-1308.

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