A research on application of Actiwatch to monitor the locomotor activity in mice

Abstract

Abstract: AIM: Using Actiwatch to monitor the locomotor activity in mice and verifying the correlation between Actiwatch and manual counting.METHODS: Thirty mice were randomly divided into three groups(control, diazepam and caffeine group), compared the synchronized data of locomotor activity of mice in jiggle-cage, which recorded by manual counting and Actiwatch, then made a correlation analysis.RESULTS: Both the Actiwatch and manual counting results showed that diazepam group had significant difference from control group and caffeine group, P<0.01; However control group had little difference from caffeine group, P>0.05. The correlation coefficient of movement time and activity number which recorded by Actiwatch and manual counting respectively were 0.83 and 0.91.CONCLUSION: The data recorded by Actiwatch and manual counting have a close correlation, and Actiwatch can be used to monitor the locomotor activity in mice.

Key words: Actiwatch, Mice, Locomotor activity, Jiggle-cage

CLC Number:

R965.1

LIU Jing, XU Jiang-tao. A research on application of Actiwatch to monitor the locomotor activity in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(7): 759-762.

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