Abstract: AIM: To investigate the accommodation of polysaccharide extracts from different genus of Dendrobium to the immunologic function in mice. METHODS: The splenic lymphocytes of mice were cultured in different concentration of polysaccharide extracts from Dendrobium candidum, Dendrobium devonianum, Dendrobium aphyllum and Dendrobium crystallinum Tchb. F. After that the effect to splenic lymphocytes proliferation was observed. Treated mice by p.o. different doses of Dendrobium polysaccharide then determined carbon clearance capacity. RESULTS: Dendrobium devonianum polysaccharide extracts could stimulate lymphocyte proliferation, increase carbon clearance capacity and spleen index, had a similar function with Dendrobium candidum. The polysaccharide extracts from other Dendrobium had no activity in enhancing immunization. CONCLUSION: Dendrobium devonianum polysaccharide could enhance spleen immune function.

Key words: Dendrobium devonianum, Polysaccharide, Immunization