Research progress in molecular mechanism of the pharmacological actions of leonurine

Abstract

Abstract: Leonurine is the unique compound found only in Herba Leonuri. In recent years, there are many reports about molecular mechanisms of leonurine pharmacological actions, which is different from the traditional indications, for instance, cardiovascular protective, neuroprotection, and anti-diabetic effects, et al. The underlying mechanisms may be related to its antioxidant, antiapoptotic, modulation of mitochondrial function and anti-inflammatory and many others. This article summarizes the pharmacological actions and the underlying molecular mechanisms of leonurine, the purpose of which is to deepen the relevant study of leonurine and facilitate its clinical use.

Key words: Leonurine, Molecular mechanism, Cardiovascular protective, Neuroprotection, Anti-diabetic

CLC Number:

R966

HE Chun-hui, ZHAO Yi-qing, LI Xia, ZHOU Lu-yao. Research progress in molecular mechanism of the pharmacological actions of leonurine[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(12): 1419-1423.

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