Abstract: AIM: To study the effect of Yunnan hongyao and other 5 like products on VEGF and MMP-1 levels of uterine tissue in dysfunctional uterine bleeding (DUB) rats. And explore the repair-mechanism of endometrium of these drugs. METHODS: The models of DUB were established by administering intragastrically with mifepristone and misoprostol to pregnant rats. After management, the clotting time were observed, and the VEGF and MMP-1 levels of uterine tissue were determined with ELISA method. RESULTS: Compared with the model group, the clotting time were significantly decreased (P<0.01) in Yunnan hongyao and 5 like products groups. In addition, the level of VEGF of uterine tissue was significantly decreased and the level of MMP-1 was significantly increased in model group. Compared with the model group, the levels of VEGF were significantly increased in Yunnan hongyao,Gong xuening and Wujia shenghua groups (P<0.01 or 0.05), and the level of MMP-1 was significantly decreased in Yunnan hongyao+estradiol valerate group (P<0.05).CONCLUSION: Yunnan hongyao and 5 like products have significant therapeutic effect on DUB rats. Yunnan hongyao,Gong xuening and Wujia shenghua can repair endometrium. The mechanism is relevant to increasing the levels of VEGF.

Key words: Yunnan hongyao, Dysfunctional uterine bleeding, Endometrium, Repair, VEGF, MMP-1