Clinical research and progress of the driver genes of lung adenocarcinoma

Abstract

Abstract: Lung cancer is one of the most common malignant tumors worldwide, which seriously harm human health. Nowadays, the causal relationship between the development of lung cancer, especially lung adenocarcinoma, and many driver genes, have been accepted by quite a lot of scholars. In recent years, with further research on cell signal pathways, a rising number of drugs have emerged, targeting different signaling pathways. In this article, we carried out a summary of relevant clinical research, in order to outline the mechanisms of a variety of driver genes in lung adenocarcinoma. Besides, we sum up prospective clinical trials of effective molecular markers, to assess the curative effects of several molecular-targeted drugs. And finally, we give an outlook of future targeted therapies.

Key words: driver gene, lung cancer, targeted therapy

CLC Number:

R734.2

ZHAO Yi-chao, ZHANG Li-qin. Clinical research and progress of the driver genes of lung adenocarcinoma[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(1): 112-117.

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