Abstract: AIM: To study the protective effect of shenmai injection on mechanical ventilation associated lung injury in patients with one-lung ventilation.METHODS: 40 patients scheduled for pulmonary lobectomy were divided to two groups: group C (n=20) and group S (n=20). 0.5 mL/kg shenmai injection were given to each patient in group S, while equivalent saline to those in group C. Immediately before anesthesia induction (T₀), 30 min(T₁), 60 min (T₂), 90 min (T₃) and 120 min (T₄) after one-lung ventilation, radial and mixed venous blood samples were collected for blood gas analysis and calculation of the value of A-aDO₂ and Qs/Qt. Meanwhile, 3 mL radial blood were extracted to detect the levels of MDA, SOD, TNF-α, IL-6 and IL-10 in plasma.RESULTS: Compared with T₀, the value of Qs/Qt, A-aDO₂, TNF-α, IL-6 and IL-10 were increased in group C on T_1-4 (P<0.05). Similar changes were presented at T4 in group S. Compared with group C, the value of Qs/Qt, A-aDO₂, TNF-α, IL-6 and IL-10 were decreased in group S on T_1-4 (P<0.05).CONCLUSION: Pretreatment with shenmai injection has protective effect on mechanical ventilation associated lung injury in patients undergoing one-lung ventilation.

Key words: one-lung ventilation, shenmai injection, SOD, MDA, TNF-α, IL-6, IL-10