Abstract:

AIM: To evaluate the effect of sevoflurane combined with propofol on postoperative cognitive function and serum oxidative stress level in elderly patients with non small cell lung cancer（NSCLC）after thoracic surger.   METHODS: 116 cases of elderly patients with NSCLC after thoracic surger were randomly divided into the control group and treatment group, 58 cases in each group. The control group was given target controlled infusion of 0.08 mg·kg-1·min-1 propofol to maintain anesthesia, the experimental group was given target controlled infusion of 0.05 mg·kg-1·min-1 propofol plus 0.8MAC sevoflurane for inhalation to maintain anesthesia. Serum neuro specific enolase (NSE), amyloid protein β(Aβ), Superoxide anion radical (O^2- ), malondialdehyde (MDA), glutathione peroxidase (GSH-Px) levels, mini mental state examination (MMSE) score and safety of the two groups were compared.  RESULTS: Compared with the control group, serum levels of NSE, Aβ were lower and the MMSE score was higher in the experimental group (P<0.05). The serum levels of O^2- , MDA were lower and the serum level of GSH-Px was higher in the experimental group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). CONCLUSION: Sevoflurane combined with propofol can significantly decrease serum oxidative stress level in elderly patients with NSCLC after thoracic surgery and can reduce the impact on postoperative cognitive function while maintaing high safety.

Key words: sevoflurane, propofol, elderly patients with non small cell lung cancer, thoracoscopic resection, postoperative cognitive function, oxidative stress