Recognition of the clinical application and biological mechanism of ursodeoxycholic acid in liver diseases

Abstract

Abstract:

Ursodeoxycholic acid （UDCA）has been widely used in clinical treatment of liver disease due to its hepato-protective effect, including primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and cystic fibrosis (CF), etc. Lack of effective drug as control, UDCA's clinical effect and mechanism of action remain unclear. Recently, the reports about adverse events caused by UDCA, especially at high dosage have been increasing. This review summarizes the clinical application and mechanism of UDCA in treatment of liver diseases, which is referential for its clinical application.

Key words: ursodeoxycholic acid, liver disease, cholagogue, toxicity

CLC Number:

R575

ZHANG Linlin, FAN Yujuan, TAN Bo, LI Yue, JIANG Jian, QIU Furong. Recognition of the clinical application and biological mechanism of ursodeoxycholic acid in liver diseases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(2): 233-240.

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