Abnormal regulation of autophagy in inflammatory bowel disease and the intervention of traditional Chinese medicine

doi:10.12092/j.issn.1009-2501.2019.04.017

Abstract

Abstract:

Autophagy is a lysosome-mediated cell-programmed degradation pathway that plays an important role in maintaining cell homeostasis, eliminating intracellular toxic substances and the balance of metabolic energy. Research shows that autophagy is closely related to the dysregulation of inflammatory immune response, pathogen invasion and the repair of intestinal mucosa, and is an important mechanism of inflammatory bowel disease (IBD). These findings are important for understanding the mechanisms of IBD and optimizing existing treatment strategies. In this review, the commonly used traditional Chinese medicines for IBD treatment were summarized from the perspective of autophagy regulation. The implications of autophagy regulation on the mechanism of research related Chinese medicine ingredients and the problems and development trends of related research were discussed.

Key words: autophagy, traditional Chinese medicine, inflammatory bowel disease, clinical treatment

CLC Number:

R932
R574.1

FAN Qilin，ZHENG Xiao，WANG Shumei，HAO Haiping，LI Ping. Abnormal regulation of autophagy in inflammatory bowel disease and the intervention of traditional Chinese medicine[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(4): 471-480.

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