Abstract: AIM: To observe the effect of Ping Yang Jiang Ya Fang on blood pressure and insulin resistance (IR)in Gan Yang Shang Kang Syndrome model of spontaneous hypertensive rats(SHR), and to explore its hypotensive effect and possible underlying mechanisms. METHODS: Twenty-four SHR were randomly divided into four groups with 6 rats in each group, all of the SHR were drenched with Aconiti Praeparatae Decoction for four weeks to make Gan Yang Shang Kang Syndrome model.Another six healthy Wistar rats were taken as normal control group.From the fifth week, each SHR group was drenched with low or high dose of Ping Yang Jiang Ya Fang Decoction (8 g/kg, 16 g/kg), the suspension of nitrendipine (1.6 mg/kg)or distilled water for thirty consective days, once a day.After the first intragastric administration, the tail artery systolic pressure of all rats was measured at every two hours for twenty-four hours in order to observe the acute hypotensive effect of drugs.And it was also measured at every three days during drenching drugs in order to observe its chronic hypotensive effect. The changes of the fasting plasma glucose (FPG), fasting insulin (FINS), insulin sensitivity index (ISI)and resistin of all rats were also determined before and after therapy. RESULTS: (1)In the acute hypotensive experiment, low or high dose of Ping Yang Jiang Ya Fang Decoction and nitrendipine could reduce the tail artery systolic pressure of SHR(P <0.05), but therewas no significant difference in twenty-four hours among them (P >0.05).The changes of systolic pressure of SHR in the groups with low dose or high dose of Ping Yang Jiang Ya Fang Decoction were smaller than those with nitrendipine during twenty-four hours (P <0.05).In the chronic hypotensive experiment, they could also decrease the tail artery systolic pressure of SHR (P < 0.05).The hypotensive effect of high dose of Ping Yang Jiang Ya Fang Decoction was better than that of low dose (P <0.05).(2)The plasma FINS and resistin of SHR in the groups of low or high dose of Ping Yang Jiang Ya Fang Decoction, or nitrendipine were significantly decreased (P <0.05), while the ISI was significantly increased (P <0.05) after treatment. And the effect of either low or high dose of Ping Yang Jiang Ya Fang Decoction was better than that of nitrendipine (P <0.05). CONCLUSION: (1)Ping Yang Jiang Ya Fang has obvious acute and chronic hypotensive effects to Gan Yang Shang Kang Syndrome model of SHR.(2)Ping Yang Jiang Ya Fang can improve the IR of Gan Yang Shang Kang Syndrome model of SHR.

Key words: traditional, Chinese, drug, treatment, ;