Abstract: AIM: To investigate the effects of budesonide on expression of basic fibroblast growth factor and mRNA in asthmatic rats.METHODS: Thirty six male Sprague-Dawley rats were randomly divided into three equal groups, including asthma group, control group and budesonide treatment group.In this experiment, the rat model of asthma was established by the ovalbumin challenge methods.The concentration of basic fibroblast growth factor in bronchoalveolar lavage fluid(BALF) was measured by ELISA, the expression of the protein of basic fibroblast growth factor and mRNA were detected with immunohistochemistry methods and in situ hybridization methods.RESULTS: The concentration of basic fibroblast growth factor in bronchoalveolar lavage fluid, the protein and mRNA expression of basic fibroblast growth factor in lung tissue were significantly higher in the asthma group than those of control group (P<0.01) , it was much lower in the treatment group than that in the asthma group, but it was still higher than the control group.The epithelial cell is the chief expression cell.CONCLUSION: The basic fibroblast growth factor participates in the pathogenesis of asthma, inhaled budesonide can significantly inhabit the expression of the protein and mRNA of basic fibroblast growth factor in the acute stage of asthma,and prevent the airway remodeling.

Key words: asthma, basic fibroblast growth factor, budesonide, rat