Welcome to Chinese Journal of Clinical Pharmacology and Therapeutics,Today is Chinese

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2005, Vol. 10 ›› Issue (4): 371-376.

Previous Articles     Next Articles

Relationship between transforming growth factor-β1 signal transduction and renal fibrosis of diabetes

WANG Jian-yun, YIN Xiao-xing   

  1. Department of Pharmacy, Xuzhou Medical College, Xuzhou 221002, Jiangsu, China
  • Received:2005-01-31 Revised:2005-03-16 Online:2005-04-26 Published:2020-11-19

Abstract: Diabetic nephropathy is one of the leading causes of the end-stage renal failure, and its major patho-logic feature is the renal fibrosis.Transforming growth factor-β1 is a key factor in the progression of the disease. Two signal pathways, Smads and MAPK following the fac-tor, are closely connected with extracellular matrix accu-mulationwhich leads to renal fibrosis.Smads and MAPK also have a cross talk in extracellular matrix accumula-tion.The relationship between the two signal pathway and ECM accumulation offers us a new therapeutic strategy for renal fibrosis of diabetes.

Key words: diabetic nephropathy, transforming growth factor-β1, renal fibrosis, Smads, MAPK

CLC Number: