Abstract: Aim To establish a model of the injury of the vascular endothelial cell (KVEC) in rats and observe the function of Chinese herbs of Li Qi Huo Xue (LQHX) will prevent and treat the VEC injury. Methods 30 SD rats were divided into the control, the model and LQHX groups. The model of the VEC injury was established. It tried to demonstrate the effect of LQHX for the coagulation and fibrinolysis function of the V EC by the CEC count, t-PA,PAI activity,6-keto-PGF_1α content and PAg T_max. Results In LQHX group as compared with those of the medol group,The CEC count was redued obviously (P <0.01) t-PA activity was increased (P<0.01), so did the percentage of active t-PA (P<0.01), but PAI activity decreased (P<0.05) 6-keto-PGF_1α content increased (P <0.01),the PAg T_max decreasd (P<0.01). Conclution LQHX can enhance the anticoagulation and fibrinolysis activities It is a more effective measure for the VEC protection

Key words: li qi huo xue, chinese herbs, vascular endothelial cell, rat