Protective effects of penehyclidine hydrochloride on transient forebrain ischemia reperfusion injury in gerbils

Abstract

Abstract: AIM: To study the protective effects of penehyclidine hydrochloride (PHC)on transient forebrain ischemia reperfusion injury in gerbils.METHODS: The model of transient forebrain ischemia reperfusion was established in gerbils by bilateral carotid artery clamping. The effects of PHC on neurological function scores and the morphous of hippocampal pyramidal neuron of gerbils were observed after receiving transient forebrain ischemia reper-fusion.SOD activities and contents of MDA in the hippocampus and cortex of gerbils were measured.RESULTS: In the groups of PHC 0.08, 0.24 mg·kg ^-1 and atropine, the stroke index was decreased, compared with the ischemia-reperfusion group after the gerbils received transient forebrain ischemia reperfusion for six hours. PHC could reduce the degree of injury in hippocampal pyramidal neuron after ischemia reperfusion for three days. CONCLUSION: PHC has protective effects on transient forebrain ischemia reperfusion injury in gerbils.

Key words: cerebral ischemia, gerbils, muscarinic receptors, superoxide dismutase, malondialdehyde

CLC Number:

R965.1

MA Teng-fei, JIN Rong, ZHANG Jing, GU Shu-ling, DUAN Shi-ming. Protective effects of penehyclidine hydrochloride on transient forebrain ischemia reperfusion injury in gerbils[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(4): 453-457.

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