Clinical issues and research progress of antioxidant therapy on ischemic stroke

Abstract

Abstract: Antioxidants, which act as neuroprotective agents on ischemic stroke, can significantly reduce injury caused by oxidative stress. However, their low effectiveness and side effects greatly limit the clinical development. Studies have shown that reactive oxygen species (ROS) is not only the core factor in ischemic brain injury, but also involved in the tissue repair in convalescence. Therefore, the obstacles of antioxidant clinical use may be associated with its complex physiological functions. The aim of this article is trying to find how to optimize the usage of antioxidants. Thereby the multiple physiological roles of ROS and the antioxidant therapy after ischemic stroke were reviewed. The usage issues of antioxidants were analyzed as well. It is supposed to provide new perspective reference for basic research and clinical applications of antioxidants.

Key words: Reactive oxygen species, Ischemic stroke, Antioxidants, P-glycoprotein

CLC Number:

CEN Juan, ZHANG Feng, JI Bian-sheng. Clinical issues and research progress of antioxidant therapy on ischemic stroke[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(4): 448-454.

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