MiRNA and interindividual difference in drug response

Abstract

Abstract: The current focus of interindividual differences in drug response is primarily studying on the phenotypic effects of SNPs and other genetic variations (such as copy number variations) in drug-metabolizing and drug-target genes, which cannot fully explain the interindividual variations in drug response. miRNAs are non-coding endogenous short RNAs which binding to the 3'untranslated region (3'UTR) of its target gene and marking them for degradation and/or translation inhibition at the post- transcriptional level. miRNA can negative control a large human gene expression, including many pharmacokinetics and pharmacodynamics genes, consequently, miRNA play very important roles in altered therapeutical efficacy. Expression levels of drug metabolism, drug transport and drug targets can be regulated by miRNA. miRNA and its binding site polymorphisms can influence gene expression, thus affecting drug response. In this review, we summarized the regulation of miRNA in drug therapy.

Key words: miRNA, Interindividual difference, Drug response, Gene polymorphisms

CLC Number:

R968

GUO Yu, ZHOU Hong-hao, LIU Zhao-qian. MiRNA and interindividual difference in drug response[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(4): 443-448.

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