Effects of Xuebijing for injection on neutrophil TCTP expression in Acinetobacter baumannii sepsis rats

Abstract

Abstract: AIM: To study the effect of Xuebijing for injection on neutrophilic granulocyte expressing translationally controlled tumor protein(TCTP) in Acinetobacter baumannii sepsis rats.METHODS: Forty-two male Wistar rats were randomized into three groups: control group (n=6),sepsis group(n=18),Xuebijing group(n=18). After successfully building sepsis models by intra-peritoneal injecting Acinetobacter baumannii suspension, according to the time of the extracting neutrophilic granulocyte in blood, sepsis group and Xuebijing group were randomly divided into 3 subgroups respectively: 6 h, 12 h and 24 h(n=6). Through the Western-blotting method to detect the expression of neutrophil TCTP. Compare them in each subgroup of sepsis group and Xuebijing group.RESULTS: Compared with the control group, sepsis subgroups of neutrophil TCTP expression were increased (P<0.05). Compared with sepsis subgroups, the expression of TCTP in neutrophil of Xuebijing subgroups were decreased (P<0.05).CONCLUSION: Xuebijing for injection in the treatment of sepsis might be related to the inhibition of neutrophil TCTP expression.

Key words: Xuebijing for injection, Acinetobacter baumannii, Sepsis, Rat, Ttranslationally controlled tumor protein

CLC Number:

R631

HE Xian-di, YAN Pei-e, ZHOU Qi, WANG Hua-xue. Effects of Xuebijing for injection on neutrophil TCTP expression in Acinetobacter baumannii sepsis rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(1): 29-32.

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