Epigenetic modulation——A novel therapeutic strategy for tamoxifen resistance

Abstract

Abstract: Tamoxifen (TAM) is a synthetic non-steroid anti-estrogen drug, which is widely used to treat estrogen receptor (ER) positive breast cancer patients. However, about 40% ER positive patients develop acquired-resistance of TAM. Epigenetics is a totally new research direction. In this review, we will focus on the current progress of epigenetic regulation of mechanisms underlying TAM resistance, in order to get a better understand of TAM resistance and provide a new strategy for breast cancer therapy.

Key words: breast cancer, tamoxifen resistance, epigenetic modulation, DNA methylation, transcriptional silencing

CLC Number:

R968

LOU Xiao-ya, SUN Hong, ZHOU Hong-hao. Epigenetic modulation——A novel therapeutic strategy for tamoxifen resistance[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(4): 460-465.

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