关键词: 菌群失调, 反复呼吸道感染, 免疫功能

Abstract: Objective To explore the effect of intestinal flora imbalance on immune function in children with recurrent respiratory tract infection (RRTI). Methods The objects of observation were RRTI children of shelter treatment in Yidu Central Hospital of Weifang and Qingzhou Traditional Chinese Hospital from May 2014 to September 2016,and divided into the group of flora imbalance,non flora imbalance group by the existence of intestinal flora imbalance.The control group were 80 cases of children without RRTI by random extraction.The situation of bacterial flora imbalance were compared in different age groups. Results RRTI group was significantly higher than the control group in incidence rate of flora imbalance,especially in the age of 3,3~6 years old of age,this was statistically significant(P<0.05).RRTI group was significantly lower than the control group in IgA level in the age of 3,3~6 years old of age,this was statistically significan(P<0.05).There was no significant difference between the two groups in IgM level,IgG level(P>0.05). Conclusions Intestinal flora imbalance may be an important risk factor with RRTI in children under 6 years old,this may be related to the reduction of immunoglobulin after flora imbalance.Timely detection of intestinal flora,improvement of intestinal micro ecological environment have a positive meaning to prevention of RRTI.

Key words: flora imbalance, recurrent respiratory tract infection, immune function