Abstract: Objective To systematically review the correlation between simple obesity and birth weight in children,and provide a theoretical basis for the control and prevention children' simple obesity. Methods Case-control study about the correlation between Chinese children's simple obesity and birth weight were collected in PubMed,EMbase,Web of science,CNKI,CBM,VIP and WanFang Data,which were published from January 2000 to November 2014.Meta-analysis was conducted by using RevMan 5.1 software. Results Finally 18 studies including 17 442 participants were included.The results of meta-analysis showed that high birth weight children had a higher risk of simple obesity with a significant difference compared with the normal weight group(OR=2.09,95%CI:1.90~2.30,P<0.000 01).In addition,it showed that no significant differences were found between children's simple obesity and low birth weight (OR=0.92,95%CI:0.41~2.06,P=0.84). Conclusion High birth weight is a risk factor of simple obesity,while no correlation exists between low birth weight and simple obesity in children.

Key words: birth weight, simple obesity, children, meta-analysis, case-control study

摘要： 目的 系统评价我国儿童单纯性肥胖与出生体重的相关性,为控制和预防儿童单纯性肥胖提供理论依据。方法 计算机检索PubMed、EMbase、Web of science、CNKI、CBM、VIP和WanFang Data,收集关于中国儿童单纯性肥胖与出生体重关系的病例-对照研究,检索时限2000年1月-2014年11月。采用RevMan5.1软件进行Meta分析。结果 最终纳入18个研究,共17 442例研究对象。Meta分析结果显示:与正常体重组相比,高出生体重儿童发生单纯性肥胖的危险性较高,差异有统计学意义[OR=2.09,95%CI:1.90~2.30,P<0.000 01];儿童单纯性肥胖在低出生体重方面差异无统计学意义[OR=0.92,95%CI:0.41~2.06,P=0.84]。结论 高出生体重是儿童单纯性肥胖的危险因素;低出生体重与儿童单纯性肥胖无关联。

关键词: 出生体重, 单纯性肥胖, 儿童, Meta分析, 病例-对照研究
中图分类号:R179 文献标识码:A 文章编号:1008-6579(2015)10-1077-04 doi:10.11852/zgetbjzz2015-23-10-21