journal1 ›› 2019, Vol. 27 ›› Issue (1): 87-90.DOI: 10.11852/zgetbjzz2018-0503

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Analysis of the related factors for allergic disease secondary to necrotizing enterocolitis

ZOU Shan-ye, LI Qu-bei   

  1. Children's Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing Key Laboratory of Pediatrics, Chongqing 400014 ,China
  • Received:2018-04-19 Online:2019-01-10 Published:2019-01-10
  • Contact: LI Qu-bei,


邹善叶, 李渠北   

  1. 重庆医科大学附属儿童医院呼吸科/儿童发育疾病研究教育部重点实验室/儿童发育重大疾病国家国际科技合作基地/儿科学重庆市重点实验室,重庆 400014
  • 通讯作者: 李渠北,
  • 作者简介:邹善叶(1992-),女,四川人,在读硕士研究生,主要研究方向为小儿呼吸系统疾病。

Abstract: Objective To investigate the correlated factors for allergic disease secondary to necrotizing enterocolitis (NEC) in newborns,in order to provide evidence for clinical diagnosis and treatment. Methods The clinical data of 137 neonates with NEC from 1st January to 31st December,2014 were analyzed and followed-up for three years. The related factors for secondary allergic disease were evaluated by Logistic regression analysis. Results The rate of anaphylactic disease was 36.50% (50/137) after three-year follow-up. Multivariate Logistic regression analysis showed that second-hand smoking(OR=2.833,95%CI:1.066-7.532) and family history of allergy(OR=4.637,95%CI:1.652-13.013) were the independent risk factors of allergic disease in NEC children (P<0.05),while breastfeeding(OR=0.152,95%CI:0.042-0.547) for at least first 4 months,positive result of fecal occult blood (OR=0.338,95%CI:0.141-0.811) were associated with lower incidence of allergic disease. Conclusions Allergic diseases after NEC are related to many factors. Second-hand smoking and family history of allergy increase the incidence of NEC,so these factors should be avoided. Meantime,breastfeeding is an effective means to reduce the occurrence of allergic diseases that is supposed to be encouraged.

Key words: necrotizing enterocolitis, allergic disease, children

摘要: 目的 分析新生儿坏死性小肠结肠炎(NEC)后发生过敏性疾病的相关因素,为临床诊治提供参考依据。方法 2014年1月1日—12月31日对在重庆医科大学附属儿童医院初诊的137例NEC患儿进行3年随访,调查过敏性疾病的发生情况,并进行继发过敏性疾病危险因素的多因素Logistic回归分析。结果 137例NEC患儿中50例(36.5%)发生过敏性疾病。多因素Logistic回归分析显示,被动吸烟(OR=2.833,95%CI:1.066~7.532)、直系亲属过敏史(OR=4.637,95%CI:1.652~13.013)为NEC患儿发生过敏性疾病的独立危险因素(P<0.05);而母乳喂养(OR=0.152,95%CI:0.042~0.547)、大便隐血阳性(OR=0.338,95%CI:0.141~0.811)为其保护因素(P<0.05)。结论 NEC后过敏性疾病与较多因素有关,其中被动吸烟与直系亲属过敏史可增加NEC后过敏性疾病的发生率,需尽量避免和预防,提倡母乳喂养是减少过敏性疾病发生的有效手段。

关键词: 新生儿坏死性小肠结肠炎, 过敏性疾病, 儿童

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