Chinese Journal of Child Health Care ›› 2024, Vol. 32 ›› Issue (1): 49-53.DOI: 10.11852/zgetbjzz2023-0084

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Research advance in the changes of bone mineral density during puberty


  1. Department of Pediatrics, Tangdu Hospital, Air Force Military Medical University, Xi'an, Shaanxi 710038, China
  • Received:2023-01-30 Revised:2023-05-19 Online:2024-01-10 Published:2024-01-04
  • Contact: LAN Li,


程轲, 兰莉   

  1. 空军军医大学唐都医院儿科,陕西 西安 710038
  • 通讯作者: 兰莉,
  • 作者简介:程轲(1989-),男,硕士研究生,住院医师,主要从事儿童生长发育研究。

Abstract: Bone mineral density is an important indicator of bone nutrition. The bone mineral density of children gradually increases with age, and the accumulation of bone mineral density in adolescence increases significantly, which is the most sensitive period to affect the peak bone mass. Sex hormone promotes bone formation and bone mineral density acquisition, and the peak secretion of growth hormone and insulin-like growth factor-1 increases bone mineral density accumulation. Children with precocious puberty develop earlier, and the length of puberty is shortened, resulting in changes in bone mass accumulation. GnRHa(gonadotrophin releasing hormone analogue) treatment of precocious puberty also affects bone metabolism. The level of 25-(OH)D3 in children varies with age in a U-shaped curve, which is the lowest in adolescence. Changes in body composition such as bone mass in adolescence have a long-term impact on bone health and even adult physique.

Key words: puberty, bone mineral density, precocious puberty

摘要: 骨密度是反映骨营养状况的重要指标。儿童骨密度随年龄逐渐增加,青春期骨密度累积大幅度提速,是影响峰值骨量最敏感的时期。性激素促进骨形成与骨密度获得,生长激素和胰岛素样生长因子-1分泌峰值提升骨密度累积。性早熟儿童青春期发育提前,青春期时长多有缩短,带来骨量累积的改变,促性腺激素释放激素类似物(GnRHa)治疗性早熟的同时影响骨代谢。儿童25-(OH)D3水平随年龄变化呈“U形曲线”,且青春期最低。青春期骨量等体成分改变对骨健康、乃至成年体质产生长远影响。

关键词: 青春期, 骨密度, 性早熟

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