Abstract: Objective To research the relationship between the level of insulin-like growth factor-I (IGF-I) and the nutrition state of children with functional dyspepsia. Methods A total of 50 cases of children with functional dyspepsia were selected as the observation group,and 50 cases of healthy children as the control group,both of whom were within 1~7 years old.The levels of serum IGF-I,PA,RBP,TRF,ALB and FFA were checked on each single child and analysis data were rendered and processed by means of SPSS18.0 statistical software. Results The level of serum IGF-I of the functional dyspepsia children was significantly lower than that of the healthy children,nutrition indicators of PA,RBP,TRF also were lower than those of the healthy children( t values were 7.60,5.00,2.50,2.40,P<0.05),but there were not obvious differences of free fatty acids and ALB (t values were 0.15、1.1,P>0.05). Conclusions Children with functional dyspepsia have a digestive disturbance,the barrier of children's absorption of nutrients disorder,and reduction of PA,RBP,TFR,which leads to decrease the serum IGF-I content.Lower level of IGF-I will affect growth and development of the functional dyspepsia children.

Key words: functional dyspepsia, children, insulin-like growth factor-I, nutrition

摘要： 目的 研究功能性消化不良儿童血清胰岛素样生长因子I(IGF-I)水平变化及其对营养状况影响,探讨功能性消化不良患儿IGF-I与营养关系。方法 选取年龄1~7岁,符合功能性消化不良诊断标准儿童为观察组50例,健康儿童为对照组50例,每例均检测血清IGF-I、前白蛋白(PA)、视黄醇结合蛋白(RBP)、转铁蛋白(TRF)、白蛋白(ALB)及游离脂肪酸(FFA)水平,使用SPSSl8.0统计软件处理数据。结果 功能性消化不良儿童血清IGF-I含量明显低于健康对照组,其营养指标前白蛋白、视黄醇结合蛋白、转铁蛋白同样低于健康对照组,差异有统计学意义(t值分别是7.60、5.00、2.50、2.40,P<0.05),而游离脂肪酸和白蛋白未见明显差异性(t值分别是0.15、1.1,P>0.05)。结论 功能性消化不良儿童消化功能异常,营养吸收障碍,体内合成前白蛋白、视黄醇结合蛋白、转铁蛋白减少,导致血清IGF-I含量下降,低水平IGF-I影响着患儿生长发育。

关键词: 功能性消化不良, 儿童, 胰岛素样生长因子I, 营养