journal1 ›› 2020, Vol. 28 ›› Issue (11): 1234-1238.DOI: 10.11852/zgetbjzz2019-1995

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Meta-analysis of vitamin D and the risk of allergic rhinitis in children

SHE Ning-ning, SHAO Na, XIA Cui, FENG Ya-ni, ZHANG Yi-tong, LIU Hai-qin, REN Xiao-yong   

  1. Department of Otorhinolaryngology Head and Neck Surgery,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi 710004,China
  • Received:2019-12-31 Revised:2020-03-10 Online:2020-11-10 Published:2020-11-10
  • Contact: REN Xiao-yong,


折宁宁, 邵娜, 夏翠, 冯雅妮, 张一彤, 刘海琴, 任晓勇   

  1. 西安交通大学第二附属医院耳鼻咽喉头颈外科病院,陕西 西安 710004
  • 通讯作者: 任晓勇,
  • 作者简介:折宁宁(1992-),女,陕西人,博士研究生,主要研究方向为睡眠呼吸障碍疾病的基础研究。

Abstract: Objective To evaluate the correlation between serum vitamin D(Vit D) level and the risk of allergic rhinitis (AR) in children by Meta-analysis. Methods Case-control studies on the correlation between serum Vit D level and childhood AR published till 15th May in 2019 were searched in computer databases.Literature was selected according to strict inclusion and exclusion criteria and data were cross-extracted to perform Meta-analysis. Results Totally 11 articles involving 3 262 participants were included,of whom 1 718 in AR group and 1 544 in control group.Meta-analysis results indicated that serum Vit D level in AR group were significantly higher than that in control group (SMD=-1.31,95%CI:-1.85--0.77,P<0.001).Vit D2 level of AR group was significantly lower than that of control group(SMD=-0.17,95%CI:-0.32--0.01,P<0.001).Moreover,Vit D3 level of AR group was significantly lower than that of control group(SMD=-3.09,95%CI:-3.57--2.61,P<0.001).Subgroup analysis showed the heterogeneity of the experimental results was reduced,which may be influenced by factors such as diet and lighting in different regions. Conclusion Vit D level in children with AR is significantly lower than that in control group,especially Vit D3,suggesting Vit D3 deficiency may be an important factor for AR in children.

Key words: vitamin D, allergic rhinitis, Meta-analysis

摘要: 目的 采用Meta分析的方法综合评价血清中Vit D水平与儿童变应性鼻炎(AR)发生风险的相关性,以求为儿童AR的预防和治疗提供新思路和途径。方法 计算机检索中英文数据库中公开发表的关于血清中Vit D与儿童AR相关性的病例对照研究,检索时限至2019年5月15日。按照严格的纳入与排除标准筛选文献、交叉提取数据资料,进行Meta分析。结果 共计纳入11篇文献,共3 262名研究对象,AR组1 718名,对照组1 544名。结果显示:AR组血清中Vit D水平低于对照组的表达,差异有统计学意义(SMD=-1.31,95%CI:-1.85~-0.77,P<0.001)。AR组Vit D2水平低于对照组,差异有统计学意义(SMD=-0.17,95%CI:-0.32~-0.01,P<0.001)。AR组Vit D3水平低于对照组,差异有统计学意义(SMD=-3.09,95%CI:-3.57~-2.61,P<0.001)。以地区进行亚组分析,其实验结果异质性均有所降低,考虑不同地区饮食、光照等因素对其有一定的影响。结论 AR儿童的Vit D水平明显低于正常组,尤其以Vit D3下降明显,因此提出Vit D3缺乏可能是导致儿童AR发生的重要因素。

关键词: 维生素D, 变应性鼻炎, Meta分析

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