journal1 ›› 2020, Vol. 28 ›› Issue (3): 288-291.DOI: 10.11852/zgetbjzz2019-0450

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Review on the correlation among vitamin D,autophagy,immunomodulation and diseases of various body systems in children

XING Na, REN Li-hong   

  1. The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, China
  • Received:2019-04-04 Online:2020-03-10 Published:2020-03-10
  • Contact: REN Li-hong, E-mail:


邢娜, 任立红   

  1. 哈尔滨医科大学附属第二医院,黑龙江 哈尔滨 150081
  • 通讯作者: 任立红,
  • 作者简介:邢娜(1992-),女,内蒙古人,硕士在读,主要研究方向为儿科风湿免疫。

Abstract: Vitamin D,as a kind of fat-soluble steroid hormones,has an extensive and complex effect to human body by interacting with specific receptors.Vitamin D receptor (VDR) is represent in a variety of tissue cells,most commonly seen in organs such as small intestine,kidney,parathyroid gland and skeleton.In addition,cardiovascular,gastrointestinal tract,central nervous system and other organs also have the expression of the vitamin D receptor.The body will appear the corresponding pathological changes when serum vitamin D level is abnormal,including respiratory diseases,digestive tract diseases,urinary system diseases,rheumatic immune diseases,autoimmune diseases,obesity and other diseases.This paper summarizes the correlation of vitamin D,autophagy;immune regulation and diseases of various systems.

Key words: vitamin D, autophagy, immunomodulation, diseases of various body systems

摘要: 维生素D对人体作用广泛且复杂,是一种与特异性受体相结合而发挥作用的一类脂溶性类固醇激素,其受体在多种组织细胞中都有分布,含量最多的器官为小肠、肾脏、甲状旁腺及骨骼,此外,心血管、胃肠道、中枢神经系统等其他脏器也有维生素D受体的表达。血清维生素D水平异常时,机体会出现相应的病理改变,如:呼吸道疾病、消化道疾病、泌尿系统疾病、风湿免疫疾病、自身免疫性疾病、肥胖等疾病,本文就维生素D水平、自噬、免疫调节及各系统疾病的相关性进行综述。

关键词: 维生素D, 自噬, 免疫调节, 各系统疾病

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