Abstract: Objective To analyze the correlations of hyperuricemia (HU) with dietary vitamin D intake in male youngsters, in order to provide new preventive method to male youngsters with HU. Methods Totally 800 male youngsters undergoing health examination in Yueqing People's Hospital Affiliated to Wenzhou Medical University from January 2019 to October 2020 were enrolled into this study and were divided into study group(HU group,n=380) and control group(n=420) according to the serum level of uric acid. The serum levels of vitamin 25(OH)D₃, TC, HDL-C, LDL-C, TG, fasting blood-glucose (FBG), calcium and phosphate were detected and compared between the two groups. The dietary vitamin D intake was assessed using a validated semi-quantitative food frequency questionnaire and compared between the two groups. The correlations of the serum levels of uric acid with the serum levels of vitamin 25(OH)D₃ and the dietary vitamin D intake were confirmed by Pearson linear correlation analysis. The risk factors of HU to the above indexes were confirmed by multivariate Logistic analysis. The diagnostic value of the dietary vitamin D intake to the HU of the male youngsters was analyzed by receiver operating characteristic curves (ROC). Results Compared with control group, the serum levels of vitamin 25(OH)D₃, HDL-C and the dietary vitamin D intake of the study group were significantly lower (t=4.863, 23.791, 12.347, P<0.05), while the serum levels of LDL-C and TC of the study group were higher (t=10.606, 12.090, P<0.05). But there were no significant difference on the serum levels of TG, FBG, calcium and phosphate between the two groups (P>0.05). The negative correlations of the serum levels of uric acid with serum levels of vitamin 25(OH)D₃ (r=-0.803, P=0.024) and the dietary vitamin D intake (r=-0.726, P=0.031) were found. Multivariate Logistic analysis showed that the higher serum levels of vitamin 25(OH)D₃ and the higher dietary vitamin D intake were independent protective factors for HU in male youngsters (OR=0.465, 0.245, P<0.05). When the cut-off point of the dietary vitamin D intake was 4.8 μg/d, the AUC of predictions to the HU in male youngsters was 0.816 and the sensitivity was 88.4% and specificity was 92.3%. Conclusions Dietary vitamin D intake and the serum levels of vitamin 25(OH)D₃ are negatively associated with HU in male youngsters. The male youngsters with HU should enhance the dietary vitamin D intake and improve the serum levels of vitamin 25(OH)D₃.

Key words: hyperuricemia, vitamin D, vitamin 25(OH)D₃, youngsters, ROC analysis

摘要： 目的 分析男性少年儿童维生素D(VD)摄入量与高尿酸血症(HU)患病的相关性,为防治少年男童HU提供思路。方法 选取2019年1月—2020年10月在乐清市人民医院健康体检的800例男性少年儿童,根据血清尿酸水平分为研究组(HL组)和对照组(血清尿酸水平正常)。测定并比较两组血清维生素25(OH)D₃、TC、HDL-C、LDL-C、TG、空腹血糖(FBG)、血钙、血磷指标的差异。通过半定量膳食频率问卷调查比较两组膳食VD摄入差异。Pearson相关分析评估血清尿酸水平与血清25(OH)D₃以及膳食VD摄入量的相关性。通过校正多因素的Logistic回归模型分析膳食VD摄入量及血清25(OH)D₃水平与HU患病率的危险程度。绘制受试者工作特征曲线(ROC)评估膳食VD摄入量对男性少年儿童HU患者患病的预测价值。结果 与对照组相比,研究组血清25(OH)D₃、HDL-C及膳食VD摄入量较低(t=4.863、23.791、12.347,P<0.05),而LDL-C及TC较高(t=10.606、12.090,P<0.05),但TG、FBG、血钙、血磷指标差异无统计学意义(P>0.05)。男性少年儿童HU患者血清尿酸水平分别与血清25(OH)D₃水平(r=-0.803,P=0.024)及膳食VD摄入量(r=-0.726,P=0.031)负相关。膳食VD摄入量高及血清25(OH)D₃水平高为男性少年儿童罹患HU的保护性因素(OR=0.465、 0.245, P<0.05)。ROC曲线显示,膳食VD摄入量截断值为4.8 μg/d,预测男性少年儿童罹患HU的AUC为0.816,灵敏度为88.4%,特异度为92.3%。结论 男性少年儿童HU患者血清25(OH)D₃水平及膳食VD摄入量低下,应予以加强补充膳食VD的摄入,提高血清25(OH)D₃水平。

关键词: 高尿酸血症, 维生素D, 血清25(OH)D₃, 少年儿童, ROC分析