Abstract: Objective To investigate serum levels of 25-hydroxyvitamin D[25(OH)D] and its correlation with pulmonary functions and IgE,and to analyse the relationship between 25(OH)D and asthma. Methods A total of fifty asthma children treated in pediatrics of Weifang Maternity and Children Healthcare Hospital from 2015 to 2016 were chosen as asthmatic group,while 50 healthy children were selected as control group.Serum 25(OH)D and IgE were tested by ELISA.And pulmonary function indicators,including forced vital capacity (FVC),forced expiratory volume in 1 second (FEV₁) and FEV₁/FVC% were measured by a device testing pulmonary function.Serum levels of 25(OH)D between asthmatic group and control group were compared,while its correlation with severity of asthma was calculated. Results The level of serum 25(OH)D was significantly lower in children with asthma(19.54±7.85)than that in control group(25.28±3.48)(t=5.679,P＜0.05).Positive correlation existed between vitamin D levels and FVC,FEV₁and FEV₁/FVC% (r=0.375,0.339,0.384).A negative relationship existed between vitamin D levels and IgE serum levels (r=-0.534). Conclusions Vitamin D deficiency is prevalent in children with asthma.There is a strong correlation between 25(OH)D and asthma severity.

Key words: vitamin D, asthma in children, pulmonary functions, serum IgE

摘要： 目的 了解支气管哮喘急性发作期儿童的血清25羟维生素D[25(OH)D]水平,分析其与肺功能、血清IgE之间的相关性,以进一步发现维生素D与儿童哮喘的关系。方法 调查2015-2016年潍坊市妇幼保健院50名哮喘急性发作儿童和50名健康儿童,用酶联免疫法检查血清25(OH)D和IgE浓度,用肺功能仪检测急性发作患儿的用力肺活量(FVC)、第1秒最大呼气量(FEV₁)、第1秒最大呼气率(FEV₁/FVC%)。分析两组儿童血清25(OH)D含量差异,及哮喘组患儿血清25(OH)D水平与急性发作严重程度的相关性。结果 支气管哮喘急性发作期儿童血清25(OH)D浓度为(19.54±7.85)ng/ml,显著低于对照组(25.28±3.48) ng/ml,差异有统计学意义(t=5.679,P<0.05)。血清25(OH)D水平与急性发作儿童的FVC、FEV₁及FEV₁/FVC%之间呈正相关(r=0.375、0.339、0.384),与IgE之间呈负相关(r=-0.534)。结论 哮喘儿童存在维生素D缺乏,血清25(OH)D与哮喘发作的严重程度存在关联。

关键词: 维生素D, 儿童哮喘, 肺功能, 血清IgE