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中国临床药理学与治疗学 ›› 2024, Vol. 29 ›› Issue (2): 207-214.doi: 10.12092/j.issn.1009-2501.2024.02.011

• 综述与讲座 • 上一篇    下一篇

仑卡奈单抗在早期阿尔兹海默病治疗中的研究进展

靳盼盼1,2,刘  洋1,2,邱  博2,吴惠珍1,2   

  1. 1河北医科大学研究生学院,石家庄  050017,河北; 2河北省人民医院药学部,石家庄  050051,河北


  • 收稿日期:2023-08-21 修回日期:2023-10-01 出版日期:2024-02-26 发布日期:2024-02-02
  • 通讯作者: 吴惠珍,女,硕士,主任药师,硕士生导师,研究方向:临床药学。 E-mail:13582005982@163.com
  • 作者简介:靳盼盼,女,硕士研究生,研究方向:临床药学。 E-mail:1549047844@qq.com
  • 基金资助:
    河北省自然科学基金青年基金项目(H2020307020)

Research progress in the treatment of early Alzheimer's disease with lecanemab

JIN Panpan1,2, LIU Yang1,2, QIU Bo2, WU Huizhen1,2   

  1. 1Graduate School of Hebei Medical University, Shijiazhuang 050017, Hebei, China; 2Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051, Hebei, China
  • Received:2023-08-21 Revised:2023-10-01 Online:2024-02-26 Published:2024-02-02

摘要:

仑卡奈单抗(lecanemab)是一种用于治疗伴有轻度认知功能障碍或轻度痴呆早期阿尔茨海默病(AD)的新药。它是一种人源性抗Aβ原纤维的单克隆IgG1抗体,通过静脉注射进入患者体内,透过血脑屏障进入大脑,清除淀粉样蛋白斑块,使患者认知功能下降速度减慢,延缓疾病进展。本文从仑卡奈单抗的药理研究、临床研究、安全性及局限性等方面进行综述,以帮助临床全面了解该药物的研究现状和已有成果。

关键词: 仑卡奈单抗, 阿尔兹海默病, 淀粉样蛋白β, 临床研究, 安全性

Abstract:

Lecanemab is a new drug used to treat early Alzheimer's disease (AD) with mild cognitive impairment or mild dementia. It is a human anti-Aβ fibril monoclonal IgG1 antibody, which is injected intravenously into the patient, through the blood-brain barrier into the brain, clearing amyloid plaque, thereby slowing the rate of cognitive decline in patients and delaying disease progression. This article reviews the pharmacological studies, clinical studies, safety and limitations of lecanemab, in order to help clinical understand the current research status and existing achievements of this drug.

Key words: lecanemab, Alzheimer's disease, amyloidβ, clinical research, security

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