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中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (4): 371-373.

• 基础研究 • 上一篇    下一篇

岩柏草总黄酮抗大鼠肝纤维化的实验研究

王福根, 庄让笑, 方红英, 张袆奇, 席建军   

  1. 浙江中医药大学附属第六人民医院,杭州 310014,浙江
  • 收稿日期:2011-04-15 修回日期:2011-04-23 发布日期:2011-06-22
  • 作者简介:王福根,男,硕士,副主任药师,研究方向:肝病药物的研发和基础研究。Tel: 0571-85463955 E-mail: WFG85463955@126.com

Empirical study of total flavonoids of selaginella moellendorfii hieron on hepatic fibrosis rat

WANG Fu-gen,ZHUANG Rang-xiao,FANG Hong-ying,ZHANG Yi-qi,XI Jian-jun   

  1. The Sixth Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine,Hangzhou 310014,Zhejiang,China
  • Received:2011-04-15 Revised:2011-04-23 Published:2011-06-22

摘要: 目的: 探讨岩柏草总黄酮对实验性肝纤维化大鼠的保护作用。 方法: 采用50%CCl4皮下注射8周,在造模同时分别灌胃15、30、60 mg/kg 剂量岩柏草总黄酮混悬液,并以水飞蓟宾为实验对照。8周后处死大鼠,对大鼠肝脏纤维化评分,并检测血清和肝组织各指标。 结果: CCl4造模结束后,大鼠肝组织病理结果显示其肝纤维化处于III-IV期;与模型组比较,岩柏草总黄酮能显著降低大鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)和肝组织中丙二醛(MDA)水平,明显升高肝组织中超氧化物歧化酶(SOD)水平,显著改善大鼠肝纤维化的病理形态。 结论: 岩柏草总黄酮对CCl4 诱导的大鼠肝纤维化有较好的保护作用。

关键词: 肝纤维化, 四氯化碳, 岩柏草, 黄酮

Abstract: AIM: To explore the protective effect of Selaginella moellendorfii Hieron on experimental hepatic fbrosis rat. METHODS: Hepatic fibrosis model was made by subcutaneous injection 50% carbon tetrachloride (CCl4) for 8 weeks,and then were intragastric administered with total flavonoids of Selaginella moellendorfii Hieron suspension(15,30,60 mg/kg),silybin was experimental control group.All rats were killed after 8 weeks,the score of hepatic fibrosis and the index in liver tissue and serum were evaluated. RESULTS: The result showed that the hepatic fibrosis was in III-IV stage. Compared with the model group,total flavonoids of Selaginella moellendorfii Hieron could significantly decrease the levels of ALT,AST in serum,and the MDA in liver tissue,and increase the level of SOD.The pathomorphology of hepatic fibrosis rat was improved. CONCLUSION: Total flavonoids of Selaginella moellendorfii Hieron have a better protective effect on rat hepatic fibrosis induced by CCl4.

Key words: Hepatic fibrosis, Carbon tetrachloride, Selaginella moellendorfii Hieron, Flavonoids

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