晚期糖基化终产物及其受体RAGE在糖尿病血管并发症中的作用机制

摘要/Abstract

摘要： 糖尿病血管并发症是糖尿病致死、致残的主要原因,其发病机制尚未完全阐明。目前大量研究表明,晚期糖基化终产物(AGEs)及其受体RAGE在糖尿病血管并发症的发生、发展中起重要作用,将成为治疗糖尿病血管病变的一个新靶点。本文重点阐述AGEs-RAGE系统的信号转导机制及其在糖尿病血管病变中的作用,并探讨中药干预AGEs-RAGE系统治疗糖尿病血管病变的现状和发展趋势。

关键词: AGEs-RAGE系统, 糖尿病血管并发症, 中药

Abstract: Diabetic vascular complications are the major causes of death and disability in patients with diabetes, its pathogenesis is not yet fully elucidated. Currently a large number of researches show that advanced glycation end products (AGEs) and its receptor RAGE play an important role in the occurrence and development of diabetic vascular complications, which suggests that the AGE-RAGE system will be a novel therapeutic target for preventing diabetic vascular complications. In this study, we reviewed the signal transduction mechanisms and the role of the AGEs-RAGE system in diabetic vascular complications, and also discussed the current situation and the development trend of traditional Chinese medicine intervention on AGE-RAGE system.

Key words: AGEs-RAGE system, diabetic vascular complications, Chinese medicine

中图分类号:

R966

乔爱敏, 李乐, 刘青. 晚期糖基化终产物及其受体RAGE在糖尿病血管并发症中的作用机制[J]. 中国临床药理学与治疗学, 2014, 19(11): 1306-1311.

QIAO Ai-min, LI Le, LIU Qing. Mechanism of action of advanced glycation end products and their receptors RAGE contribute to the development of diabetic vascular complications[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(11): 1306-1311.

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