Abstract: Aim To investigate the effect of Zhanggukangchi capsule on estrogen level and the development of periodontal tissue in rats.Methods Forty female rats were divided into experimental and control groups in the former.Every rat was perfused with 1 ml Zhuang gukangchifluidper day in the latter, and rats were perfused with distilled water, and 30 days later, the est radial content was detected, and the weight of rat body and their utero-ovarian were measured;In addition, another 32 female rats were also divided into experimental and cont rol groups and fed as discribed aboue.Every 4 rats from each group were killed in 1, 4, 8 and 12 weeks respectively. The histolo gical characte ristics of periodontal tissue materials were observed with light microscope.Results The est radial content, weight of ute ro-o variam, and index of uters/a rium in experimental group were hig her significantly than those in the control group (P<0.01)and gingival epthelial hy perplasia, pericementum and periodontal fibre were thickened.Conclusion It is revealed that Zhuang gukangchicapsule may increase extrogen level distinctly and promote the development of periodontal tissue.

Key words: rat, estrogen, Zhuanggukangchi capsule, periodontal tissue