1 Blackburn EH.Telomerases.Ann Rev Biochem, 1992;61: 113
2 Greider CW. Telomere leng th regulation.Ann Rev Biochem, 1996;65:337
3 Morin GB.The human telomere terminal transferase enzyme is a ribonucleoprotein that sy nthesizes TTAGGG repeats.Cell, 1989;59:521
4 Chong L, Steensel BV, Broccoli D, et al.A human telomeric protein.Science, 1995;270:1663
5 Harrington L, Mcphail T, Mar V, et al.A mammalian telomerase-associated protein.Science, 1997;275:973
6 Kim NW, Piaty szek MA, Prowse KR, et al.Specific association of human telomerase activity with immor tal cells and cancer.Science, 1994;266:2011
7 Feng JL, Funk WD, Wang SS, et al.The RNA component of human telomerase.Science, 1995;269:1236
8 Fu WM, Beg ley JG, Killen MW, et al Anti-apoptotic role of telomerase in Pheochromo cy toma cells.J Biol Chem, 1999;274:7264
9 Ma ta JE, Joshi SS, Palen B, et al.A hexameric phosphoro thioate oligonucleotide telomerase inhibitor arrests grow th of Burkitt lymphoma cells in vitro and in vivo.Toxicol Appl Pharmacol, 1997;144:189
10 Nielsen PE, Egholm M, BergRH, et al.Sequence-selective recog nition of DNA by strand displacement with a thymine-substituted poly amide.Science, 1991;254:1497
11 Nor ton JC, Piatyszek MA, Wright WE, et al.Inhibition of human telomerase activity by peptide nucleic acids.Nature Biotech, 1996;14:615
12 Kanazaw a Y, Ohkawa K, Ueda K, Mita E, et al.Hammerhead ribozyme-mediated inhibition of telomerase activity in ex tracts of human hepatocellular carcinoma cells. Biochem Bio phy Res Commun, 1996;225:570
13 Yo koyama Y, Takahashi Y, Shinohara A, et al.Attenuation of telomerase activity by a hammerhead ribozyme targeting the template reg ion of telomerase RNA in endometrial carcinoma cells.Cancer Res, 1998;58:5406
14 Strahl C, Blackburn EH.The effects of nucleoside analogs on telomerase and telomeres in tetrahymena.Nucleic Acids Res, 1994;22:893
15 Fletcher TM, Salazar M, Chen SF.Human telomerase inhibition by 7-deaza-2-deo xypurine nucleoside triphosphates. Biochemistry 1996;35:15611
16 Pai RB, Pai SB, Kukhanov a M, et al.Telomerase from human leukemia cells:proper ties and its interaction with deox ynucleoside analogues.Cancer Res, 1998;58:1909
17 Ku WC, Cheng AJ, Wang TC.Inhibition of telomerase activity by PKC inhibitors in human nasopharyng eal cancer cells in culture.Biochem Biophy Res Commun, 1997;241: 730
18 Li H, Zhao LL, Yang ZY, et al.Telomerase is contro lled by protein kinase C in human breast cancer cells.J Biol Chem, 1998;273:33436
19 Sharma HW, Sokoloski JA, Perez JR, et al.Differentiation of immortal cells inhibits telomerase activity.Proc Natl Acad Sci USA, 1995;92:12343
20 Bestilny LJ, Brown CB, Miura Y, et al.Selective inhibition of telomerase activity during terminal differentia tion of immor tal cell lines.Cancer Res, 1996;56:3796
21 Savoysky E, Yo shida K, Ohtomo T, et al.Down-regulation of telomerase activity is an early event in the differentiation of HL60 cells.Biochem Biophy Res Commun, 1996; 226:329
22 Zhang LP, Jiang JK, Tan RG.Effects of matrine on telomerase activity and cell cycle in K562 cell.Chin J Oncol, 1998;20:328
23 Chen F, Xu G, Li Y.Regulation of telomerase activity in HL-60 and NB4 cells by arsenic trio xide.Chin J hematol, 2000;21:366
24 Zhu XL, Kumar R, Mandal M, et al.Cell cycle-dependent modulation of telomerase activity in tumor cells.Proc Natl Acad Sci USA, 1996;93:6091
25 Horikawa I, Cable PL, Afshari C, et al.Cloning and characterization of the promo ter region of human telomer ase reverse transcriptase gene.Cancer Res, 1999;59:826
26 Chin L, Artandi SE, Shen Q, et al.P53 deficiency rescues the adverse effects of telomere lo ss and cooperates with telomere dysfunction to accelera te carcinogenesis.Cell, 1999;97:527
27 Karlseder J, Broccoli D, Dai Y, et al.P53-and ATM-dependent apoptosis induced by telomeres lacking TRF2.Science, 1999;283:1321
28 Mandal M, Kumart R.Bcl-2 modulates telomerase activity.J Biol Chem, 1997;272:14183
29 Ishibashi T, Lippard SJ.Telomere loss in cells treated with cisplatin.Proc Natl Acad Sci USA, 1998;95:4219
30 Hayakawa N, No zawa K, Ogaw a A, et al.Isothiazolone derivatives selectively inhibit telomerase from human and rat cancer cells in vitro.Bio chemistry, 1999;38:11507
31 Nassani I, Seimiy a H, Tsuruo T.Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins.Bipchem Biophy s Res Commun, 1998;249:391
32 Mo rin GB.Is telomerase a universal cancer target ? J Natl Cancer Inst, 1995;87:859
33 Bry an TM, Marusic L, Bacchetti S, et al.The telomere leng thening mechanism in telomerase-neg ative immo rtal human cells does not involve the telomerase RNA subunit. Hum Mol Genet, 1997;6:921
34 Levis RW, Ganesan R, Houtchens K, et al.Transposons in place of telomeric repeats a t a Drosophila telomere.Cell, 1993;75:1083
35 Lundblad V, Blackburn EH.An alter native pa thway for yeast telomere maintenance rescues estl-senescence.Cell, 1993;73:347
36 Gibbs JB.Mechanism-based targ et identification and drug discovery in cancer research.Science, 2000;287:1969 |
