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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2002, Vol. 7 ›› Issue (1): 60-62.

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Detection of homozygous P16 gene deletion in Non-Hodgkin' s Lymphoma by semiquantitative multiplex polymerase reaction and it' s clinical signifi-cance

JI Zhao-Ning, LIU Guo-Qing, XU Dou-Rong1, HONG Wen-De1   

  1. Department of Pharmacology, China Pharmaceutical Universyty, Nanjing 210009;
    1First Hospital of San Yat-sen U-niversyty of Medical Sciences, Guangzhou 510089
  • Received:2001-02-05 Revised:2001-11-18 Online:2002-02-26 Published:2020-11-27

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Abstract: AIM: To investigate the possible relation-shop between Non-Hodgkin's lymphoma and homozygous deletion of P16 gene. METHODS: Fifty one Non-Hodgkin's lymphoma specimens were examined for ho-mozygous deletion of P16 gene by multiplex polymerase chain reaction.RESULTS: Of 51 Non-Hodgkin's lym-phoma specimens, 9 (17.65 %) showed homozygous deletion of P16 gene.There was a significant difference between the low malignancy NHL, and the high malignan-cy NHL (P <0.05) in homozygous deletion of P16 gene. CONCLUSIONS: Deletion of P16 gene might contribute to the progression of Non-Hodgkin' s lymphoma and may be one of the important parameters in estimating the prog-nosis of patients with NHL.

Key words: Non-Hodgkin's lymphoma, P16 gene, Polymerse chain reaction

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