Abstract: AIM: To evaluate the effect of polysac-charide from spirulina platensis (PSP) on hematopoietic recovery and related cytokines in mice with transplant tu-mor after treated by chemotherapy.METHODS: The tu-mor cells were subcutaneously injected in the right forefoot to induce transplant solid tumor in mice.The mice were ig with PSP for 10 d and injected intraperitoneally with cyclophosphamide (CTX) for 3 d.On d 11, the count of peripheral blood cell, nucleated cell in bone marrow and CFU-S (Colony Forming Unit-Spleen) was observed;The content of DNA in bone marrow was inspected by UV-spectrophotometer;The cytokines in serumswere inspect-ed by double antibody sandwich ELISA.RESULTS: CTX could induce evident myelosuppression.But PSP could elevate the level of peripheral blood cell, increase nucleated cell and DNA in bone marrow, and promote CFU-S formation.In addition, PSP could also increase the content of IL-1, IL-3, GM-CSF, and TNF-αin serum.CONCLUSION: It is probably that PSP acceler-ates the hematopoietic recovery in mice with transplant tu-mor treated by chemotherapy by promoting endogenous cy-tokines secretion.

Key words: polysaccharide, spirulina platensis, transplant tumor, myelosuppression, hematopoietic recov-ery, cytokines