Abstract: AIM: To evaluate efficacy and safety of oral swine serum immunoglobulins in treatment of infantile rotavirus enteritis. METHODS: 322 infants with rotavirus enteritis were randomly divided into three groups: Double-blinded control trial was carried out in 243 inpatients randomly divided into two groups (128 infants received oral swine serum immunoglobulins in the treatment group, 115 infants received placebo in the control group), and 79 outpatients as the open group received oral swine serum immunoglobulins. Every group was received 0. 5 ml·kg^-1 of oral swine serum immunoglobulins or placebo thrice daily for 3 days. RESTULTS: The total therapeutic effective rate (cure and apparent effect)and curative rate were 73. 5 % and 38. 3 % respectively in the treatment group, significantly higher than 51. 3 % and 14. 8 % in the control group (P <0. 01).The therapeutic effect of the open group was similar to the treatment group. The total therapeutic effective rate and curative rate were 81 % and 39. 2 % respectively (P >0. 05). CONCLUSION: The oral administration of swine serum immunoglobulins is effective, safe and convenient in treating rotavirus enteritis of infants.

Key words: rotavirus infection, enteritis, immunoglobulin, serum, swine